Automated Synthesis and Analysis of Switching Gene Regulatory Networks
نویسندگان
چکیده
منابع مشابه
Automated Synthesis and Analysis of Switching Gene Regulatory Networks
Studying the gene regulatory networks (GRNs) that govern how cells change into specific cell types with unique roles throughout development is an active area of experimental research. The fate specification process can be viewed as a biological program prescribing the system dynamics, governed by a network of genetic interactions. To investigate the possibility that GRNs are not fixed but rathe...
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A fundamental question in biology is how cells change into specific cell types with unique roles throughout development. This process can be viewed as a program prescribing the system dynamics, governed by a network of genetic interactions. Recent experimental evidence suggests that these networks are not fixed but rather change their topology as cells develop. Currently, there are limited tool...
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We provide a summary of Boolean network models for budding yeast cell-cycle including the Irons’ model. The model has 18 nodes and involves some auxiliary nodes which allow variability in time delays in the activation and degradation expression level of nodes. We also introduce a Boolean network exhibiting the cell-cycle behavior based on a family of cyclic codes, Projective Geometry codes, whi...
متن کاملPhenotypic switching in gene regulatory networks.
Noise in gene expression can lead to reversible phenotypic switching. Several experimental studies have shown that the abundance distributions of proteins in a population of isogenic cells may display multiple distinct maxima. Each of these maxima may be associated with a subpopulation of a particular phenotype, the quantification of which is important for understanding cellular decision-making...
متن کاملSI Appendix: Phenotypic switching in gene regulatory networks
3 Slow promoter fluctuations 5 3.1 Binary promoter switching: exact solution . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.2 General solution using the conditional LNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.1 Conditional gene product distribution . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.2 Distribution of promoter states . . . . . . . . . . . ....
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ژورنال
عنوان ژورنال: Biosystems
سال: 2016
ISSN: 0303-2647
DOI: 10.1016/j.biosystems.2016.03.012